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ENdocrinology insights
Insights & Information in Hormone Therapy and Endocrinoogy
Prescribing for Transwomen and Transmen, our articles provide insight about the clinical observations and risks related to particular hormones and common questions about Gender Endocrinology Treatment.


Information About Hormone Regimes for Transwomen / Non-Binary
Oestrogen Options: Transdermal Estradiol Patch (25/50/75/100 micrograms/24h), Transdermal Estradiol Gel, Transdermal Spray (new!) - Lenzetto, Oral Estradiol. Androgen Blocker Options, GnRH Agonist - Leuprorelin (Prostap), GnRH Agonist - Triptorelin (Decapeptyl SR), Oral Antiandrogen - Spironolactone, Finasteride, Cyproterone Acetate


Initiating Masculinising Hormone Treatment on Sustanon / Nebido / Testosterone Gel
Initiating Masculinising Hormone Treatment on Sustanon / Nebido / Testosterone Gel. Recommended starting doses: 1. Sustanon (or testosterone enantate) 250mg every 4 weeks. 2. Nebido 1000mg every 12 weeks (usually after established on short-acting T). 3. Gel – Testogel pump 40.5mg daily / Testogel sachets 50mg daily / Tostran pump 40mg daily


Informed Consent for Testosterone
Answers to Questions about Testosterone. How is Testosterone taken? Who is at higher risk of health problems if they take Testosterone? What Testosterone does to your body?


Consent for Hormone Clinic Service for Gender Identity
Our detailed consent forms have information regarding what to expect from cross sex hormones, common side-effects and complications: Informed Consent for Estradiol; Informed Consent for Testosterone. We provide hormone care. We are not commissioned to provide or arrange any investigations. We will offer dose titration, administration, initiation, duration of treatment, monitoring, interpretation of laboratory results and likely treatment effects.


What is Hormone Treatment of Gender Dysphoria?
Our gender endocrine services offer hormone treatment that provides effective and timely treatment for trans and non-binary people in the following way: Prescribe medicines for the treatment of gender dysphoria; Follow recommendations for safety and treatment monitoring


Information about Hormone Regimens
Prescribing for Transmen, Injectable Testosterone - Sustanon, Brand names: Sustanon, Starting dose: 250 mg every 4 weeks, Directions: 1ml injection IM. Avoid in peanut/soya allergy, Frequency/dose range: 2-6 weeks, Further treatment: If periods persist after 6 months of adequate testosterone treatment, a GnRH agonist such as Leuprorelin (11.25mg 3 monthly) or a long-acting form of progestogenic contraception can be added


Information About Treatment with Estradiol
Answers to Questions about Estradiol. How is estradiol taken? Who is at higher risk of health problems if they take estradiol? What estradiol does to your body


Switching between Testosterone Preparations
Testosterone is normally started in a short acting formulation such as a gel or injectable (Sustanon/Enanthate) with initial monitoring at 4-6 months and with dose titrations up to target range. For risks of testosterone therapy, please see detailed information available on our consent forms for testosterone which are located on our health professional hormone support hub on our website.


Initiating Feminising Hormone Treatment on Oral or Transdermal Estrogen
FEMINISING HORMONE TREATMENT ON ORAL OR TRANSDERMAL ESTROGEN. Recommended starting doses; 1. Transdermal estradiol – patch 25–50mcg twice weekly or gel 0.5- 1.5mg daily; 2. Oral estradiol – 1 or 2mg daily
Consider lower starting doses in older patients or those with CV risk factors Oral estrogen may increase VTE risk.


How to give a Testosterone Intramuscular (IM) Injection
What is an intramuscular injection? An intramuscular injection delivers medication directly into the muscle. This allows the medication to be quickly absorbed into the bloodstream


Estradiol Equivalent Doses
What is Progesterone? Progesterone belongs to a group of steroid hormones called ‘Progestogens’ or ‘Progestins’ that are produced by the ovaries during the menstrual cycle. Progestogens are secreted by the ovary at higher levels in the first 10 weeks of pregnancy followed by the placenta in later pregnancy.


Information About Treatment with Triptorelin/Leuprorelin to Lower Testosterone Levels in Gender Dysphoria
Leuprorelin is a synthetic hormone (also known as a Gonadotrophin Releasing Hormone agonist or GnRHa) which can be used to reduce the levels of testosterone circulating in the body. It may be given alone, or alongside oestrogen, to improve feminisation by helping to: Reduce the amount of body and facial hair; Reduce sex drive; Reduce erectile activity; Reduce muscle size and strength


How to Approach Cervical Screening for Transmen and Non-Binary Individuals – for Health Professionals
There are several things to consider when a transman or non binary, assigned female at birth individual presents for routine cervical screening. It is important to remember that cervical screening in a transman or non-binary individual can cause significant distress and further exacerbate their dysphoria. Engaging with a health practitioner to discuss this and have a vaginal examination can be difficult and very confronting especially when there is dysphoria around their geni


Troubleshooting and FAQs for Transmasculine/Non-Binary Individuals on Testosterone Treatment
Considerations of other aspects of long term care for Transgender Non-binary individuals: Considerations of other aspects of long term care for Transgender Non-binary individuals in Feminising and Masculinising Treatment. Such as how to Approach Cervical Screening for TGNB Individuals – Info for Health Professionals


Troubleshooting and FAQ for Transfeminine/Non-binary individuals on Feminising Treatment
Considerations of other aspects of long term care for Transgender Non-binary individuals: Considerations of other aspects of long term care for Transgender Non-binary individuals in Feminising and Masculinising Treatment. Such as how to Approach Cervical Screening for TGNB Individuals – Info for Health Professionals


Information Regarding Progesterone:
What is Progesterone? Progesterone belongs to a group of steroid hormones called ‘Progestogens’ or ‘Progestins’ that are produced by the ovaries during the menstrual cycle. Progestogens are secreted by the ovary at higher levels in the first 10 weeks of pregnancy followed by the placenta in later pregnancy.


How to Approach Vaginal Bleeding for Transmen and Non-Binary Individuals on Testosterone Treatment
The aim of this document is to provide a framework to sensitively assess the significance of the bleeding, examine and investigate appropriately. There is an absence of clear guidelines in this area and cases should be considered on an individual basis.
Transgender Hormone Treatment
Gender Endocrinology
Offering services for patients with a supportive gender dysphoria/ incongruence diagnosis
What You Need to Know Videos
The Patient Journey
Dr Victoria Millson-Brown explains the YGES Clinic journey, what to expect, and key information
our services
We provide hormone treatments for Gender Endocrinology
Dr Victoria Millson-Brown is a transgender expert and has over a decade of NHS experience as a general physician and a further 5 years in higher specialty training to qualify as a Consultant Endocrinologist.
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